RPR Test (Syphilis)
RPR Test (Syphilis) can be requested without a referral, and this overview covers what to expect. The RPR (rapid plasma reagin) test is a blood test used to screen for syphilis, a sexually transmitted infection caused by the bacterium Treponema pallidum. It detects antibodies the body may produce in response to infection. It is often ordered when someone has symptoms, a known exposure, or as part of routine screening.
- Sample type
- blood
- Category
- Sexual Health
- Turnaround
- 1-3 business days
- Price
- $49
- Referral
- Not required
The RPR (rapid plasma reagin) test is a blood test used to screen for syphilis, a sexually transmitted infection caused by the bacterium Treponema pallidum. It detects antibodies the body may produce in response to infection. It is often ordered when someone has symptoms, a known exposure, or as part of routine screening.
What it measures
- Reagin antibodies — Antibodies that can appear in the blood during syphilis infection.
- RPR titer — A number that shows how much antibody is present; higher numbers may indicate active infection.
- Reactive or nonreactive result — A simple positive or negative screening result.
- Confirmatory test result — A second, more specific test is often used to confirm a reactive RPR.
Who it is for
A healthcare clinician may order this test if you have symptoms of syphilis, may have been exposed, or are due for routine screening. Screening is common during pregnancy and for people with certain risk factors.
Preparation
No fasting or special preparation is needed for this blood test. Tell your clinician about any medications or health conditions that could affect the result.
Results and what they mean
Results are usually reported as reactive (positive) or nonreactive (negative), sometimes with a titer number. A reactive result does not always mean active syphilis, so a clinician may order a confirmatory test and interpret the results in context. This is general information only and not medical advice; discuss your results with a qualified clinician.
How to order this test
- Choose the test and place a confidential order online.
- Select a certified collection site and pick a time that suits you.
- Have your specimen collected — most draws take only a few minutes.
- Review results in a secure portal, typically within 1–3 days.
Preparation, hours, and pricing vary by site; confirm details directly with the lab before your visit.
Availability by state
Direct-access online ordering for the rpr test (syphilis) is available in most states. It is currently unavailable in 6 states:
Everywhere else you can order confidentially and collect your sample at a certified site. Browse by state →
Frequently asked questions
Does a reactive RPR mean I definitely have syphilis?
Not necessarily. The RPR is a screening test, and other conditions can sometimes cause a reactive result. A clinician usually orders a more specific test to confirm.
How long after exposure can the RPR detect syphilis?
It can take several weeks after exposure for the test to become reactive. If you test too soon, a clinician may recommend retesting later.
Is the RPR test painful?
It is a standard blood draw from a vein in your arm. Most people feel only a brief pinch.
Will my results be kept private?
Yes. Your results are confidential and are shared with you and your clinician as part of your medical care.