Ovarian Cancer Blood Test
Ovarian Cancer Blood Test is a laboratory test you can order directly. The ovarian cancer blood test measures proteins in the blood that can be elevated in ovarian cancer. It is most often used to help evaluate a pelvic mass or to monitor treatment in someone already diagnosed, not as a routine screening test for all women.
- Sample type
- blood
- Category
- Cancer Screening
- Turnaround
- 1-3 business days
- Price
- $158
- Referral
- Not required
The ovarian cancer blood test measures proteins in the blood that can be elevated in ovarian cancer. It is most often used to help evaluate a pelvic mass or to monitor treatment in someone already diagnosed, not as a routine screening test for all women.
What it measures
- CA-125 — A protein that can rise with ovarian cancer, but also with benign conditions like endometriosis or pregnancy.
- HE4 — Another protein that may be elevated in ovarian cancer; sometimes used with CA-125 to improve accuracy.
- ROMA score — A calculated number that combines CA-125, HE4, and menopause status to estimate risk.
- CEA — A marker that can help distinguish ovarian cancer from cancers of the digestive tract.
- AFP — A protein that may be checked in younger women to rule out certain rare ovarian tumors.
Who it is for
A doctor may order this test if you have symptoms such as bloating, pelvic pain, or a pelvic mass, or if you have a strong family history of ovarian or breast cancer. It is also used to follow response to treatment in someone with known ovarian cancer.
Preparation
No fasting or special preparation is usually needed. Tell your doctor about any medications or recent procedures, as some can affect the results.
Results and what they mean
Results are reported as numbers for each marker, often with a reference range. A higher value does not mean you have cancer, and a normal value does not rule it out. Only a clinician can interpret these results in the context of your symptoms, imaging, and history. This is general information, not medical advice.
How to order this test
- Choose the test and place a confidential order online.
- Select a certified collection site and pick a time that suits you.
- Have your specimen collected — most draws take only a few minutes.
- Review results in a secure portal, typically within 1–3 days.
Preparation, hours, and pricing vary by site; confirm details directly with the lab before your visit.
Availability by state
Direct-access online ordering for the ovarian cancer blood test is available in most states. It is currently unavailable in 6 states:
Everywhere else you can order confidentially and collect your sample at a certified site. Browse by state →
Frequently asked questions
Can this test screen for ovarian cancer in all women?
No. It is not recommended as a routine screening test for women without symptoms or high risk, because it can miss cancer and also give false alarms.
What if my CA-125 is high?
A high CA-125 can be caused by many things besides cancer, including fibroids, endometriosis, or infection. Your doctor will likely order imaging or other tests to find the cause.
Do I need to fast before this test?
No fasting is required. You can eat and drink normally unless your doctor gives other instructions.
How long do results take?
Most results are ready within 1 to 3 business days, though this can vary by lab.