Tryptase Level Test
This page explains the tryptase level test, what it measures, and how to arrange it. A tryptase level test measures the amount of tryptase, an enzyme released by certain immune cells called mast cells, in your blood. It is usually ordered to help evaluate severe allergic reactions, repeated flushing or hives, or a suspected mast cell disorder.
- Sample type
- blood
- Category
- Allergy
- Turnaround
- 1-3 business days
- Price
- $119
- Referral
- Not required
A tryptase level test measures the amount of tryptase, an enzyme released by certain immune cells called mast cells, in your blood. It is usually ordered to help evaluate severe allergic reactions, repeated flushing or hives, or a suspected mast cell disorder.
What it measures
- Total tryptase — The overall amount of tryptase enzyme in your blood.
- Baseline tryptase — A level taken when you are well, used for comparison over time.
- Acute tryptase — A level taken soon after symptoms, which may be higher during a reaction.
- Tryptase change over time — How much the level rises or falls between samples.
Who it is for
Tryptase testing is typically ordered by allergists, immunologists, emergency or internal medicine clinicians, and other specialists evaluating severe allergic reactions or possible mast cell conditions.
Preparation
No fasting is usually required. Timing matters: your clinician may ask for a sample during or shortly after symptoms and another sample later when you feel well, so follow the specific timing instructions you are given.
Results and what they mean
Results are reported as a number, often in nanograms per milliliter (ng/mL), and may be compared with a previous sample or a reference range. A single value does not confirm or rule out a condition; a clinician interprets it alongside your symptoms, timing, and other tests. This is general information only and not medical advice.
How to order this test
- Choose the test and place a confidential order online.
- Select a certified collection site and pick a time that suits you.
- Have your specimen collected — most draws take only a few minutes.
- Review results in a secure portal, typically within 1–3 days.
Preparation, hours, and pricing vary by site; confirm details directly with the lab before your visit.
Availability by state
Direct-access online ordering for the tryptase level test is available in most states. It is currently unavailable in 6 states:
Everywhere else you can order confidentially and collect your sample at a certified site. Browse by state →
Frequently asked questions
Do I need to fast for a tryptase test?
Fasting is not usually needed. Ask your clinician if any other tests on the same day require fasting.
Why might I need more than one tryptase sample?
Comparing a sample taken during symptoms with one taken when you are well can show whether tryptase rises during a reaction.
What can affect my tryptase result?
Timing of the sample, recent allergic reactions, and some other health conditions can affect the level. Tell your clinician about recent symptoms and medicines.
How long do results take?
Results are commonly available in about 1 to 3 business days, though this can vary by laboratory.