TCA Drug Test
TCA Drug Test is a laboratory test you can order directly. The TCA drug test detects tricyclic antidepressants (TCAs), a class of medications used mainly for depression and some types of pain. It is ordered to check whether the amount of TCA in the blood is within a safe range, especially when side effects or overdose are suspected.
- Sample type
- blood
- Category
- Drug & Urine Screening
- Turnaround
- 1-3 business days
- Price
- $499
- Referral
- Not required
The TCA drug test detects tricyclic antidepressants (TCAs), a class of medications used mainly for depression and some types of pain. It is ordered to check whether the amount of TCA in the blood is within a safe range, especially when side effects or overdose are suspected.
What it measures
- Total tricyclic antidepressants — A combined measurement of drugs such as amitriptyline, nortriptyline, imipramine, and desipramine.
- Amitriptyline — A common TCA often prescribed for depression or nerve pain.
- Nortriptyline — The active form of amitriptyline, also used as its own medication.
- Imipramine — An older TCA that may still be prescribed.
- Desipramine — A TCA related to imipramine.
Who it is for
A doctor or psychiatrist may order this test when a person takes a TCA and has concerning symptoms, or when an overdose is suspected. It may also be used to check whether a prescribed dose is producing a safe blood level.
Preparation
No special preparation is usually needed. Tell your healthcare provider about all medications and supplements you take, because some can affect the result.
Results and what they mean
Results are reported as a number for each drug or as a total level, along with the laboratory's reference range. Your clinician interprets the level in the context of your dose, symptoms, and other factors. This is general information only and not medical advice; always discuss your results with a qualified healthcare professional.
How to order this test
- Choose the test and place a confidential order online.
- Select a certified collection site and pick a time that suits you.
- Have your specimen collected — most draws take only a few minutes.
- Review results in a secure portal, typically within 1–3 days.
Preparation, hours, and pricing vary by site; confirm details directly with the lab before your visit.
Availability by state
Direct-access online ordering for the tca drug test is available in most states. It is currently unavailable in 6 states:
Everywhere else you can order confidentially and collect your sample at a certified site. Browse by state →
Frequently asked questions
Is this test the same as a urine drug screen?
No. This test uses a blood sample and measures the actual amount of tricyclic antidepressants in your blood, not just whether they are present.
How long does it take to get results?
Results are typically available within 1 to 3 business days.
Can I eat or drink before the test?
Yes, fasting is not required unless your healthcare provider gives you other instructions.
What if my level is outside the reference range?
A level outside the range does not automatically mean there is a problem. Your clinician will consider your dose, symptoms, and overall health to decide what it means for you.