Methylmalonic Acid Blood Test
Methylmalonic Acid Blood Test is a laboratory test you can order directly. The methylmalonic acid (MMA) blood test measures the level of methylmalonic acid in your blood. It is often ordered to help evaluate for vitamin B12 deficiency, especially when other tests are unclear.
- Sample type
- blood
- Category
- General Wellness
- Turnaround
- 1-3 business days
- Price
- $198
- Referral
- Not required
The methylmalonic acid (MMA) blood test measures the level of methylmalonic acid in your blood. It is often ordered to help evaluate for vitamin B12 deficiency, especially when other tests are unclear.
What it measures
- Methylmalonic acid (MMA) — A substance made during normal metabolism; high levels can suggest vitamin B12 deficiency.
- Vitamin B12 (cobalamin) — Often measured alongside MMA to give a fuller picture of B12 status.
- Homocysteine — Another marker that may rise with B12 or folate deficiency; sometimes included.
- Folate — A vitamin that works with B12; low folate can also affect MMA and homocysteine.
Who it is for
A healthcare provider may order this test if you have symptoms of vitamin B12 deficiency, such as numbness, tingling, or fatigue, or if you have a condition that affects nutrient absorption.
Preparation
No special preparation is usually needed. You may eat and drink normally unless your provider gives other instructions.
Results and what they mean
Results are reported as a number for MMA, often with a reference range. Your clinician interprets the result along with your symptoms, diet, and other tests. This is general information only and not medical advice; talk with your provider about what your results mean.
How to order this test
- Choose the test and place a confidential order online.
- Select a certified collection site and pick a time that suits you.
- Have your specimen collected — most draws take only a few minutes.
- Review results in a secure portal, typically within 1–3 days.
Preparation, hours, and pricing vary by site; confirm details directly with the lab before your visit.
Availability by state
Direct-access online ordering for the methylmalonic acid blood test is available in most states. It is currently unavailable in 6 states:
Everywhere else you can order confidentially and collect your sample at a certified site. Browse by state →
Frequently asked questions
Do I need to fast for this test?
Usually no. Fasting is not required unless your provider asks you to fast for other tests.
What can cause a high MMA level?
A high level may be due to vitamin B12 deficiency, kidney problems, or certain inherited conditions. Your provider will consider your full health picture.
How is this test different from a vitamin B12 test?
MMA can rise earlier and more specifically when B12 is low, so it may help confirm a deficiency when B12 alone is borderline.
Is this test covered by insurance?
Coverage depends on your plan and why the test is ordered. Check with your insurance provider or the lab for details.