Hexamethylene Diisocyanate (HDI) Allergy Test
Below is a plain-language overview of the hexamethylene diisocyanate (hdi) allergy test. The hexamethylene diisocyanate (HDI) allergy test is a blood test that checks for antibodies your immune system may make after exposure to HDI, a chemical used in some paints, coatings, and foams. It is usually ordered when a person has workplace exposure and symptoms such as wheezing, coughing, or skin reactions that could be related to HDI.
- Sample type
- blood
- Category
- Allergy
- Turnaround
- 1-3 business days
- Price
- $49
- Referral
- Not required
The hexamethylene diisocyanate (HDI) allergy test is a blood test that checks for antibodies your immune system may make after exposure to HDI, a chemical used in some paints, coatings, and foams. It is usually ordered when a person has workplace exposure and symptoms such as wheezing, coughing, or skin reactions that could be related to HDI.
What it measures
- HDI-specific IgE — An antibody linked to immediate-type allergic reactions to HDI.
- HDI-specific IgG — An antibody that can show immune exposure to HDI, though it does not by itself confirm allergy.
- Total IgE — A general measure of allergic antibody levels, sometimes included for context.
- Serum control — A check that the sample was handled properly and the test ran correctly.
Who it is for
This test is typically ordered by allergists, occupational medicine clinicians, or primary care clinicians for people who work with HDI-containing products and have symptoms that may be work-related.
Preparation
No fasting is required. Tell your clinician about any medicines you take, because some drugs may affect antibody levels; timing may matter if symptoms are recent.
Results and what they mean
Results are usually reported as negative or positive, sometimes with a numeric level for each antibody. A positive result does not prove allergy by itself, and a negative result does not rule it out, so a clinician interprets the results alongside your history and exam. This is general information, not medical advice.
How to order this test
- Choose the test and place a confidential order online.
- Select a certified collection site and pick a time that suits you.
- Have your specimen collected — most draws take only a few minutes.
- Review results in a secure portal, typically within 1–3 days.
Preparation, hours, and pricing vary by site; confirm details directly with the lab before your visit.
Availability by state
Direct-access online ordering for the hexamethylene diisocyanate (hdi) allergy test is available in most states. It is currently unavailable in 6 states:
Everywhere else you can order confidentially and collect your sample at a certified site. Browse by state →
Frequently asked questions
Is this test painful?
It uses a standard blood draw, so you may feel a brief pinch or sting.
How long do results take?
Typical turnaround is 1 to 3 business days, though it can vary by lab.
Do I need to fast?
No. Fasting is not required for this test.
Can this test tell me if I can keep working with HDI?
No. Work decisions should be made with your clinician and workplace safety staff based on your full evaluation.