Fentanyl Screen and Confirmation
This page explains the fentanyl screen and confirmation, what it measures, and how to arrange it. A fentanyl screen and confirmation is a two-step blood test that looks for fentanyl, a powerful prescription opioid, and related drugs in the body. It is ordered when a person has symptoms suggesting opioid exposure, when monitoring prescribed fentanyl therapy, or as part of a workplace or medical evaluation. The screen gives a quick yes-or-no signal, and the confirmation step verifies that signal.
- Sample type
- blood
- Category
- Drug & Urine Screening
- Turnaround
- 1-3 business days
- Price
- $119
- Referral
- Not required
A fentanyl screen and confirmation is a two-step blood test that looks for fentanyl, a powerful prescription opioid, and related drugs in the body. It is ordered when a person has symptoms suggesting opioid exposure, when monitoring prescribed fentanyl therapy, or as part of a workplace or medical evaluation. The screen gives a quick yes-or-no signal, and the confirmation step verifies that signal.
What it measures
- Fentanyl — The main drug being detected; even small amounts can appear in blood.
- Norfentanyl — A breakdown product of fentanyl that the body makes; its presence supports recent use.
- Screen result — A first, rapid check that flags whether fentanyl may be present.
- Confirmation result — A more specific follow-up test that verifies the screen finding.
Who it is for
A doctor, emergency clinician, or employer health program typically orders this test. It may also be requested during pain-management monitoring or substance-use evaluation.
Preparation
No fasting is usually required. Tell the person collecting the sample about any prescribed fentanyl or other medicines, because these can affect the result.
Results and what they mean
Results are reported as negative or positive, with the confirmation result giving the final answer. A clinician interprets the result alongside symptoms, medicines, and history. This is general information, not medical advice; discuss your results with a qualified clinician.
How to order this test
- Choose the test and place a confidential order online.
- Select a certified collection site and pick a time that suits you.
- Have your specimen collected — most draws take only a few minutes.
- Review results in a secure portal, typically within 1–3 days.
Preparation, hours, and pricing vary by site; confirm details directly with the lab before your visit.
Availability by state
Direct-access online ordering for the fentanyl screen and confirmation is available in most states. It is currently unavailable in 6 states:
Everywhere else you can order confidentially and collect your sample at a certified site. Browse by state →
Frequently asked questions
How long does fentanyl stay in blood?
Detection time varies by dose, use pattern, and the person. Blood levels generally fall faster than urine levels, so timing matters.
What is the difference between the screen and confirmation?
The screen is a quick initial check. The confirmation is a more precise follow-up that reduces false positives.
Can prescribed fentanyl cause a positive result?
Yes. Prescribed fentanyl and some other medicines can produce a positive screen, which is why confirmation and clinical review are used.
Does a positive result mean I overdosed?
No. A positive result only shows that fentanyl was detected; a clinician must interpret what it means for your situation.